Bioassay of aniline hydrochloride for carcinogenicity.
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Bioassay of aniline hydrochloride for carcinogenicity.

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

Subjects:

  • Carcinogens.,
  • Aniline -- Toxicology.,
  • Coal-tar colors -- Toxicology.

Book details:

Edition Notes

SeriesCarcinogenesis technical report series ; no. 130, DHEW publication ; no. (NIH) 78-1385, DHEW publication -- no. (NIH) 78-1385.
The Physical Object
Pagination109 p. in various pagings :
Number of Pages109
ID Numbers
Open LibraryOL15224159M

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The National Cancer Institute conducted a bioassay of aniline hydrochloride for possible carcinogenicity using F rats and B6C3F 1 mice (NCI ). Aniline hydrochloride was administered in the feed to groups of approximately 50 male and 50 female animals of each species at concentrations of % (3, ppm) and % (6, ppm) of the diet for rats and % (6, ppm) . Bioassay of aniline hydrochloride for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Dec 05,  · A bioassay of aniline hydrochloride for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. Aniline hydrochloride was administered in the feed, at either of two concentrations, to groups of 50 male and female animals of each species, with the exception of 49 female mice in the high dose group. Bioassay for carcinogenicity of 3,2′-dimethylnitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters ☆ Author links open overlay panel Stephen S. Hecht Karam El-Bayoumy Abraham Rivenson Emerich S. FialaCited by: 7.

Sep 26,  · Bioassay of Aniline Hydrochloride for Possible Carcinogenicity (CASRN ) Long-Term Carcinogenicity TR PDF (3MB) Bioassay of Trimethylthiourea for Possible Carcinogenicity (CASRN ) Aniline hydrochloride was tested for carcinogenicity in single experiments in mice and rats by oral administration. No increase in tumour incidence was observed in mice. In rats, it produced fibrosarcomas, sarcomas and haemangiosarcomas of the spleen and peritoneal cavity [ref: 1]. Bioassay of aniline hydrochloride for possible carcinogenicity. National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland (Carcinogenesis Technical Report Series No. ). May 01,  · In the NTP bioassays aniline HCl is reported as non-carcinogenic in the mouse but in the rat it produced fibrosarcomas, sarcomas and haemangiosarcomas of the spleen and peritoneal cavity. The overall IARC classification of aniline is that there is limited evidence for carcinogenicity to animals (IARC, ).Cited by:

Get this from a library! Bioassay of 2,4-dimethoxyaniline hydrochloride for possible carcinogenicity.. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.]. The genotoxicity of a variety of aniline derivatives was examined by a DNA repair test with rat hepatocytes. Out of 37 aniline derivatives, 6 chemicals, i.e., 2,4,6-trimethylaniline (mesidine), 2,4-xylidine, 3,5-diaminobenzoic acid, 3,4-diaminochlorobenzene, 2-chloromethylaniline and 4-chloro-N-methyl-aniline, elicited positive DNA repair clic-clelia.com by: Read chapter Aniline: Aromatic Amines: An Assessment of the Biological and Environmental Effects Login Register Cart Help. Aromatic Amines: aniline-induced carcinogenicity in mice of either sex (National Cancer Institute, ~. National Cancer Institute. Bioassay of aniline hydrochloride for possible carcinogenicity. CAS No. Abstract. The utility of information acquired from the application of genetic tests to the safety evaluation of agricultural chemicals such as animal drugs or pesticides, involves the same considerations that are used for other environmental clic-clelia.com by: 4.